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Results Oral semaglutide was safe and well-tolerated in both trials
So, lets break down what we currently know about semaglutide long-term side effects and whether theyre something to be concerned about
The SUSTAIN-6 Trial (Once-Weekly Semaglutide) The Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes (SUSTAIN-6) consisted of 3297 people living with T2DM, 83% with established cardiovascular disease, receiving once-weekly semaglutide (0.5 and 1.0 mg) or placebo
This safety feature reduces hypoglycemia risk compared to insulin or sulfonylurea medications
While Ozempic and Rybelsus are not explicitly marketed as weight loss medication, Wegovy has been approved by The National Institute for Health and Care Excellence (NICE) in the UK and by the Food and Drug Administration (FDA) in the US for the treatment of obesity independently of type 2 diabetes, and will soon be available over the counter from pharmacists in the UK
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